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KMID : 0360319930250050673
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 5 p.673 ~ p.679
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Clinical Analysis of Brain Metastasis of Choriocarcinoma
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백은정
정재근/손우익/송종철/김미란/정대영/김승조
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Abstract
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Choriocarcinoma is the malignant tumor arising from fetal trophoblast and metastasized to the lung, mainly. Among the other distant metastatic sites, brain is the most serious and highly malignant form.
Between 1973 and 1992, 701 patients received chemotherapy for gestational trophoblastic tumors in the department of obstetrics and gynecology, Catholic University Medical College. A retrospective analysis has been performed of patients treated
for
brain
metastasis of 43 patients.
@ES The results were as follows;
@EN 1) the mean age on admission was 33.8 years(range 19~57, median 31).
2) Most of antecedent pregnancy was not hydatidiform mole.
3) There appears to be a tendency for metastasis to occur frequently in the left hemisphere. The parietofrontal area was the most affected area.
4) Headache associated with nausea and vomitting was the most common symptom. The next was hemiparesis and were followed visual disturbance and seizure.
5) Most of the patients had lung metastasis(84%) but. there was only brain metastasis in 15.9% of patients.
6) The most effective treatment was the combination of systemic chemotherapy and intrathecal injection with or without craniotomy and intrathecal injection with radiation therapy was the worst.
7) The most common cause of death was intracranial hemorrhage and the next was infection.
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KEYWORD
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